Prepare the Chicken:
Rinse the chicken pieces under cold water and pat dry with paper towels. Place them in a large bowl or zip-top bag and pour in the buttermilk and hot sauce. Let the chicken marinate in the fridge for at least 2 hours or overnight for best results.
Make the Cajun Spice Blend:
In a small bowl, mix paprika, cayenne pepper, garlic powder, onion powder, oregano, thyme, black pepper, and salt.
Prepare the Coating:
In a large bowl, combine the flour, cornstarch, and 2 teaspoons of the Cajun spice blend. Mix well.
Coat the Chicken:
Remove the chicken pieces from the buttermilk, letting any excess drip off. Coat each piece thoroughly in the flour mixture, pressing gently to ensure the coating sticks.
Heat the Oil:
Heat about 2 inches of vegetable oil in a large skillet or deep fryer to 350°F (175°C).
Fry the Chicken:
Carefully add the chicken to the hot oil, making sure not to overcrowd the pan. Fry in batches for 12-15 minutes, turning occasionally, until golden brown and cooked through (internal temperature of 165°F/74°C).
Drain and Rest:
Remove the chicken and place it on a wire rack lined with paper towels to drain excess oil.
Serve:
Sprinkle with a pinch of the remaining Cajun spice blend and serve hot with your favorite sides.